Beware of the lurking threats on every floor -- some are especially persistent... 
Don't You Worry About a Thing
Not unlocked yetGet the awakening ending as Axel.
In Ruins
Not unlocked yetGet the normal ending as every character.
Happily Ever After
Not unlocked yetGet the true ending as every character.
Future Legend
Not unlocked yetGet the awakening ending as every character.
Commencement
Not unlocked yetUnlock all medals associated with Jules.
Road Warrior
Not unlocked yetUnlock all medals associated with Jeff.
Family Reunion
Not unlocked yetUnlock all medals associated with Cordelia.
Freshman Orientation
Not unlocked yetUnlock all medals associated with Digby.
Lady's Man
Not unlocked yetUnlock all medals associated with Mumba.
Pay Day
Not unlocked yetUnlock all medals associated with Lydia.
Big Promotion
Not unlocked yetUnlock all medals associated with Luis.
Fit as a Fiddle
Not unlocked yetUnlock all medals associated with Fuji.
The Bad Sleep Well
Not unlocked yetUnlock all medals associated with BOSS.
Big Kahuna
Not unlocked yetUnlock all medals associated with Axel.
Fully Actualized
Not unlocked yetUnlock every medal associated with every character.
Every Nook and Cranny
Not unlocked yetExplore the entire restored mansion.
Dirty Dawg
Not unlocked yetStare at the shop screen for two minutes.
Glutton for Punishment
Not unlocked yetClear an awakening ending run on X Must Die with all 12 general curses enabled.
Uh-Oh...
Not unlocked yetTrigger a Chunks mutation.
Unbound
Not unlocked yetDefeat Tentacle Chunks.
Nice Doggy
Not unlocked yetDefeat Dog Chunks.
Keen Observation
Not unlocked yetDamage a Tanuki before it drops its disguise.
Cracked
Not unlocked yetDestroy three eggs in one room before any of them hatch.
Bone Meal
Not unlocked yetDestroy every part of a Bonefish before they disappear.