Beware of the lurking threats on every floor -- some are especially persistent... 
Exterminator
Not unlocked yetKnock out Chunks.
Secret Secret
Not unlocked yetVisit 10 secret rooms in a single run.
Hope She Notices You
Not unlocked yetPurchase Cordelia's entire stock on the first floor.
Speedrunner
Not unlocked yetComplete a run in 20 minutes or less.
Fill My Pockets
Not unlocked yetCarry over $1,000 at once.
Fill My Wallet
Not unlocked yetCarry over $2,000 at once.
Fill My Vault
Not unlocked yetCarry over $3,000 at once.
Die
Not unlocked yetDie.
Witchout a Hitch
Not unlocked yetComplete a run without taking a single hit.
Massacre
Not unlocked yetKill 6+ enemies with less than a second gap between each kill.
Another Go-round
Not unlocked yetLeap off the balcony and loop your run.
Again?!
Not unlocked yetLoop twice in a single run.
Mouse Trap
Not unlocked yetGet a Crusher in the Laboratory to land on Chunks.
Homerun Hitter!
Not unlocked yetKill a Moth using a melee weapon as it's coming at you.
Speed Demon
Not unlocked yetPress all 3 buttons in the Exit Realm within 5 minutes.
Collector
Not unlocked yetCollect 15+ items in a single run.
Hoarder
Not unlocked yetCollect 25+ items in a single run.
Klepto
Not unlocked yetCollect 35+ items in a single run.
Window Shopper
Not unlocked yetComplete a run without ever visiting a shopkeeper.
Roided Out
Not unlocked yetMax out all your stats with Dr. Cordelia.
Scrap Metal
Not unlocked yetDestroy 5+ weapons in a single run.
Happy Halloween!
Not unlocked yet
Outta the Park!
Not unlocked yetAs Digby, get a 20+ kill combo.
Shiny!
Not unlocked yetDestroy a full ammo Golden Gun as Luis.