Complete the Uprooting Evil Heroic Deed (Complete 5 Priority Assignments on any difficulty)

Complete the Magos Biologis Heroc Deed (Use booster type inoculator components 250 times)

Complete the Hero of the Imperium Heroic Deed (Acquire 750 Fate points)

Complete the No Turning Back Heroic Deed (Reach Inquisitorial Rank 20 with one character)

Complete the Where it Hurts Heroic Deed (Kill 50 Commander enemies)

Complete the Stalwart Servant Heroic Deed (Complete 15 events during missions)

Complete the Invincible Heroic Deed (Complete 25 missions without dying)

Complete the Cheating Death Heroic Deed (Activate 50 traps)

Complete the Cull the Strong Heroic Deed (Kill 100 elite enemies)

Complete the Hunter of Hunters Heroic Deed (Kill 5 Boss creatures)

Craft 25 items

Achieve the Massacre bonus for the first time

Get the Killstreak bonus 30 times

Get the Angel of Death bonus 30 times

Get the Unbreakable bonus 30 times

Fuse a socket into a Relic (or better) item

You have made a decision regarding the fate of a Psyker in the service of the Drukhari

You have sabotaged the Drukhari master plan and destroyed all of the Pain Catalysts

You have eradicated the Coterie of Dissonance from the Triglav Subsector

Unlock the Agartha Subsector

You have judged Caius Thorn for his disobedience

You have destroyed Abraxas, the infamous Chaos Knight

You have killed Kairn Golgarth, the Voidripper warlord

Reach 1500 Score in City of Suffering (City of Suffering DLC needed)