Collect or Invent 53 Tonics in the Physical, Engineering and Combat tracks

Max out all possible research

Complete the game on Hard difficulty without using a Vita-Chamber

Complete the game on Survivor difficulty without using a Vita-chamber

Rescued the Little Sister in “The ‘I’ in Team”

Rescued the Little Sister in “The ‘I’ in Team” in under 3:00

Found all collectable Roses in “The ‘I’ in Team”

Rescued the Little Sister in “The ‘I’ in Team” without destroying any Machine Gun Turrets

Rescued the Little Sister in “A Shocking Turn of Events”

The player has rescued the Little Sister in “A Shocking Turn of Events” in under 4:00

Found all collectable Roses in “A Shocking Turn of Events”

Charged up the Ferris Wheel 9 different times in “A Shocking Turn of Events”

Rescued the Little Sister in “Worlds of Hurt”

Rescued the Little Sister in “Worlds of Hurt” in under 15:00, on Medium or higher difficulty

Found all collectable Roses in “Worlds of Hurt”

Rescued the Little Sister in “Worlds of Hurt” using only plasmids, tonics, the wrench, and the research camera, on Medium or higher difficulty

The player has beaten the game on survivor difficulty.