Playing Aeon, finish the game by using Shadow Bolt to deal the killing blow on each of the guardians.

Playing Big Mo, finish the game without overheating once.

Playing Mukai, finish the game by entering every card of every level (not counting extra cards or the shortcut card)

Playing Rasimov, activate the Immortal ability 6 times and finish the game with full health.

Unlock all of Aeon's permanent upgrades.

Unlock all of Big Mo's permanent upgrades.

Unlock all of Mukai's permanent upgrades.

Unlock all of Rasimov's permanent upgrades.

In a single playthrough, upgrade 6 skills from each of the three skill trees, and equip a gold glyph.

Have 15 health.

Clear a level with special kills only.

In a single playthrough, take no damage in a 3-skull combat card. Do this 10 times.

In a single playthrough, reroll 3 shops, bypass 2 cards, and cast destiny runes once.

Kill 13 creatures with a single blow.

Upgrade the same glyph twice in a single playthrough.

In a single combat, generate 60 reflected projectiles by shooting at a reflective-aura protected creature.

Survive a One-Shot Kill card in which you lost health.

In level 4, be within the range of a doll head's swirl of minions for 20 seconds.

In a single playthrough, purchase 20 items in shops.

Finish the game with at least 7 keys, 7 energy cells and 1,500 mana.

Finish the game without purchasing a single skill upgrade.

Finish the game without opening a single locked chest or locked card.

Finish the game without using any glyph.

Survive the secret Cthulhu card in Hard mode