Kill all the tablets in two back-to-back level end tablet rainbows.

Get 50 Rainbow Bonuses in a single playthrough.

Kill 10 pills after they've passed through the shield in a single playthrough.

Kill 10 pills before they become visible on the screen in a single playthrough.

Kill all of the tablets in Tablet Frenzy.

Kill 3 pills in 0.3 seconds or less.

Kill 3 pills, switch colors 3 times, and then kill 3 more pills.

Get 12 life overfill bonuses.

Go through a Minefield level without setting off a Flashbang.

Kill 10 bombs with the shield in a single level past 50 without losing a life or detonating a bomb yourself.

Kill 20 bombs with the shield in a single level past 50 without losing a life or detonating a bomb yourself.

Clear the screen with a Monochrome powerup and then again with the opposite color Monochrome.

Deploy a Monochrome powerup and have it kill no pills.

Beat the game with only the Monochrome powerup equipped.

Kill 20 or more pills with a single Lightning powerup.

Get a Rainbow Bonus with the Lightning powerup.

Deploy a Lightning powerup when there's nothing on screen.

Kill 20 pills while invincible.

Kill 10 pills while Embiggened.

Kill 20 pills while in Slow Mo.

Chain 4 Slow Mo powerups in a row.

Have Embiggening, Invincibility, and Slo Mo active at the same time.

Detonate a bomb to kill more pills than you need to finish the level.

Kill 7 other pills with a single bomb.